GRM8 and neoplasm: Recent research reports that the transcriptional activation of Metabotropic glutamate receptor 8 (GRM8) was elucidated to promote the survival of squamous cell lung carcinoma (LUSC) tumor cell through inhibiting cAMP pathway and activating MAPK pathway and the transcription level of GRM8 was reversely correlated with the prognosis of LUSC cases (Zhang et al., 2019), which is similar to our results.