TP53 and hepatocellular carcinoma: Among them, the mutation frequency of HCC driver gene TP53 was enriched in the high-risk group (45 versus 13%, Fisher’s exact test p-value = 6.60e-10), this observation suggested the classic role of TP53 in cell-cycle regulation and guarding genome stability might also contribute to the malignant progression of HCC (Gao et al., 2019).