The 6 AFs with the most predictive value were selected (Supplementary Figures S3 and S4), including GRM8, SPC25, FSD1L, SLC38A6, FAM72A, and SLC39A10. In addition, several publications also supported these genes in cancer with experimental evidence (Supplementary Table S3), such as siRNA approach. The gene discussed is SLC39A10; the disease is cancer.