However, this study needs to be expanded in following aspects: first, our study was conducted only based on online databases and to overcome this limitation, we robustly integrated bioinformatic analyses, such as meta-analysis; second, the underlying mechanisms between TRIM8 expression and tumor immunity in breast cancer should be investigated in the future; and finally, the detail mechanisms underlying the prognostic markers remains to be elucidated. Here, TRIM8 is linked to breast cancer.