Compared with normal samples, the mRNA expression of TRIM8 was significantly up-regulated in cholangio carcinoma (CHOL), colon adenocarcinoma (COAD), Liver hepatocellular carcinoma (LIHC), Lung adenocarcinoma (LUAD), Prostate adenocarcinoma (PRAD), Rectum adenocarcinoma (READ), and thyroid carcinoma (THCA), but strongly down-regulated in breast invasive carcinoma (BRCA), kidney renal clear cell carcinoma (KIRC), Glioblastoma multiforme (GBM), kidney renal papillary cell carcinoma (KIRP), lung squamous cell carcinoma (LUSC), Uterine Corpus Endometrial Carcinoma (UCEC). The gene discussed is TRIM8; the disease is rectum adenocarcinoma.