Then, TISIDB analysis was conducted to study the correlation between TRIM8 expression and immune cells, and we found that there were negative correlations between TRIM8 expression and abundances of CD4+T cell, B cell, T follicular helper cell, Gamma delta T cell, Th1 cell, Th2 cell, and natural killer T cell in breast cancer, especially CD4+ T cell. This evidence concerns the gene CD4 and breast carcinoma.