Considering the possible involvement of MALAT1/miR-1-3p/CXCR4 axis in the pathogenesis of DN raised by our pilot study, further studies are suggested in the future exerting more samples alongside patient classification based on the quality of hyperglycemia control in order to precisely clarify the role of this axis in the etiopathogenesis of DN. This evidence concerns the gene MALAT1 and liver dysplastic nodule.