In low- and middle-income countries, pneumonia is the main infectious pathogen disease burden in the community, and after the introduction of 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine PCV10 in Kilifi County Hospital, Kenya, the number of pneumonia hospitalizations decreased dramatically, and the burden of pneumonia hospitalizations in children was greatly reduced [23]. This evidence concerns the gene DHRS2 and pneumonia.