We recently showed that male mice deficient for NF-κB/c-Rel protein (c-rel–/– mice) develop an age-dependent PD pathology and phenotype (Baiguera et al., 2012; Lanzillotta et al., 2015; Porrini et al., 2017; Parrella et al., 2019; Bellucci et al., 2020). Here, REL is linked to Parkinson disease.