Indeed, hyperactivity is a behavior observed in different PD animal models, including LRRK2 (Volta et al., 2015; Zhang et al., 2021) and α-synuclein transgenic rodents (Unger et al., 2006; Graham and Sidhu, 2010; Polissidis et al., 2021). The gene discussed is LRRK2; the disease is Parkinson disease.