NDUFV1 and Parkinson disease: MPP + is taken up by dopaminergic neurons and interferes with normal electron transfer by inhibiting the activity of mitochondrial respiratory chain complex I, which causes the increase of ROS levels and resulting mitochondrial damage, eventually leading to dopamine neuronal injury and death in the SNpc, and producing the symptoms of PD (Nakamura and Vincent, 1986; Gerlach et al., 1991; Hu et al., 2015).