GSEA of WFA-induced gene expression changes in THP1 cells revealed negative enrichment of the leukemia stem cell (LSC) self-renewal signature (Supplementary Fig. 9a), consistent with the reported importance of c-MYB in maintaining the AML LSC self-renewal program [13] and our previous data with mebendazole [26]. This evidence concerns the gene MYB and acute myeloid leukemia.