We were able to replicate association of this THSD4 variant with moderate-to-severe asthma risk in the Shrine et al. study8 (P = 0.0079, ORG-allele = 1.06), but were unable to replicate this association (using the proxy SNP in high LD with our lead variant—rs11853359, r2 = 0.93) in studies that did not enrich for moderate-to-severe asthma patients (European subset of the Demenais et al. study2, and GWAS of the asthma Phecode in the UK Biobank23)(P > 0.45 ). This evidence concerns the gene THSD4 and asthma.