MDM2 and colonic neoplasm: For example, a TP53 wild-type colon cancer organoid HCM-SANG-0266-C20 was sensitive to the MDM2 inhibitor Nutlin-3a, whereas a TP53 mutant oesophageal organoid HCM-SANG-0291-C15 exhibited little to no response to treatment; a model was deemed sensitive if the IC50 was less than the maximum screening concentration tested (Fig. 4c).