Remarkably, our findings also resemble those of a recent report, which shows that catabolism of BCAA is lost during the progression of cells toward carcinogenesis: this caused an increase in BCAA levels and mTORC1 hyperactivation; however, restoring the BCAA catabolic pathway with BT2 impaired the cancer cell proliferation [68]. The gene discussed is ARID4B; the disease is cancer.