Interestingly, Xu et al. (33) showed that crossing classical AD model mice, Tg2576, with Tg-SwDI mice, which express Dutch-E22Q and Iowa-D23N APP mutant by Thy1.2 promoter and exhibit low levels of vascular Aβ deposits, resulted in the massive deposition of vascular amyloid (34). The gene discussed is APP; the disease is Alzheimer disease.