PON1 and type 2 diabetes mellitus: There was a remarkable correlation between PON1 activity and polymorphism − 108C>T in Iranian T2D subjects in which TT genotype carriers had the lowest PON1 activity [179, 180]. There was a significant correlation between PON1 promoter polymorphism (− 108C>T) and its Arylesterase-based activity in Iranian T2DM cases compared with controls [181].