Moreover, we can also introduce TNF-α (-308G/A), NPC1(rs1805081 and rs1788799), MPO (-463G/A), TCF7L2 (rs4506565 and rs12255372), KCNJ11 (rs5219), IGF2BP2 (rs4402960 and rs1470579), VDR (rs10735810, rs731236, rs7975232, and rs1544410), TCF7L2 (rs7903146), eNOS (T786C and G894T), and ACE (C677T and I/D) polymorphisms as the candidates for the screening of the diabetes susceptibility among Iranian, Saudi Arabia, Turkish, Emirati, Syrian, Lebanese, Kuwaiti, Palestinian, Jordanian, and Bahraini populations, respectively. This evidence concerns the gene ACE and diabetes mellitus.