Normal cases carrying the GT+TT genotypes of the rs12255372 variation had a remarkably higher WHR compared with GG genotype carriers [307]. The correlation between T2DM and TCF7L2 rs12255372 variant was assessed in a subpopulation of Iranian cases in which the minor T allele of TCF7L2 rs12255372 significantly elevated the T2DM risk. Here, TCF7L2 is linked to type 2 diabetes mellitus.