Serological tests were conducted for rheumatoid factor, which increases in 50–80% of patients with rheumatoid arthritis, anti-CCP antibody, which has 98% specificity for rheumatoid arthritis diagnosis [46], CRP, which reflects a systemic inflammatory response, and hyaluronic acid, which increases in people who have experienced joint destruction [47]. This evidence concerns the gene CRP and rheumatoid arthritis.