MMP2 and neoplasm: A volcano plot revealed many differentially expressed genes (DEG) between TAb2 vs. TCh3 tumor cells, such as colony stimulating factor 1 (CSF1) and MMP2 upregulated in TAb2 tumors (Fig. 3A), suggesting that the enrichment of specific genes may explain the heterogeneous TME and differential ICI responses between TAb2 and TCh3 tumors.