PRF1 and neoplasm: However, anti-PD-L1 treatment resulted in upregulation or downregulation of numerous genes in CD45+ tumor-infiltrating immune cells in TCh3 tumors, including Cd3d, Cd3e, Cd3g, Cd8a, Cd8b1, Nkg7, Ccl5, Ets1, Icos, Cxcr6, Pdcd1, Lag3, Prf1, and Gzmb (Fig. 7E, right).