Moreover, no association was observed between GI11 (Gag)-specific T-cell responses with CD4 T-cell counts, VL, or viral set point (Fig. 4a) at 3 months of infection, whereas GI11 (Gag)-specific T-cell responses were positively associated with CD4 T-cell counts (R = 0.716, P = 0.046) at 1 year of HIV-1 infection (Fig. 4a). This evidence concerns the gene CD4 and HIV-1 infection.