Moreover, the frequency of tumour-infiltrating CD3+CTLA-4+, CD8+PD-L2+, CD8+TIGIT+, CD8+A2aR+ cells positively correlated with lymphovascular invasion (p = 0.03, p = 0.03 and p = 0.03) (Fig.1S). Here, ADORA2A is linked to neoplasm.