Therefore, this study profiles the expression of a panel of ICs beyond the PD-1 and CTLA-4 axes including TIGIT, TIM-3, LAG-3 A2aR and ICOS and CD160, which play a prominent role in mediating T cell exhaustion on circulating and tumour-infiltrating T cells in treatment-naïve and post-treatment setting. Here, ADORA2A is linked to neoplasm.