Beyond that, the number of hippocampal BrdU+/Nestin+ and BrdU+/DCX+ cells of the AD group (SAMP8) were significantly lower than those in the control group (SAMR1) (p < 0.01, Figure 6b, c), which suggested that the newborn NPCs and neurons decreased in Alzheimer‐like mice. Here, NES is linked to Alzheimer disease.