To infect NPC across the blood‐brain barrier, intravenous injection of adenovirus‐shRNA‐DMP1 (AAV‐shRNA, 25 μl, PHP.EB) and adenovirus‐shRNA‐control (AAV‐GFP, 25 μl, PHP.EB) was to inhibit DMP1 expression in the SAMP8 mice of 5 months. This evidence concerns the gene DMP1 and nasopharyngeal carcinoma.