AOAA treatment also increased the sensitivity of the colon cancer cell line oxaliplatin, significantly reducing the IC50 value, and GSH, Bcl-2, total caspase-9, and total caspase-3 expression, while increasing oxaliplatin-induced apoptosis, ROS levels, cleaved caspase-9, cleaved PARP, Bax, and p53 expression. The gene discussed is CASP9; the disease is colonic neoplasm.