TJP1 and cystic fibrosis: Castellani et al. [16] confirmed these previous results on TJ disorganization in CF cells by the lack of TJ proteins at cell-cell contacts (occludin, ZO-1, claudin 1, and JAM-1), and showed also that NHERF1 or CFTR overexpression in CFBE41o- cell (F508del homozygous) monolayers induced the reorganization of TJ proteins at the level of intercellular junctions and reduced the paracellular permeability to small solutes.