The results of an experiment on mice aiming to study the effect of melatonin on the lipid profile and the development of obesity demonstrated that melatonin supplementation attenuated serum TG, TC, and LDL-C levels and prevented body mass gain through a decreased lipogenesis rate and increased lipolytic capacity in white adipocytes, with a concomitant increment in oxygen consumption and PGC1A and PRDM16 expression [33]. This evidence concerns the gene PPARGC1A and obesity due to melanocortin 4 receptor deficiency.