Moreover, hypertensive participants who were users of ARBs or ACEis showed better preservation of memory over time than those taking other antihypertensive medications in a recent cross-sectional study [14]. The beneficial effect of ACEis on AD has also been observed in animal models of AD, with the neuroprotective profile induced by the drug being accompanied by reduced amyloidogenic processing of the amyloid precursor protein (APP) [15]. However, the latter observation has been contradicted by studies reporting that ACE reduces amyloid β (Aβ) deposition [16]. This evidence concerns the gene APP and Alzheimer disease.