However, on the account of this study, upregulation of CD43 (a modulator of inflammatory cells trafficking and adhesion) and p53 (regulator of intermediary metabolism and energy homeostasis) suggests that hyperlipidemia might aggravate cellular inflammation and predispose animals to obesity, which correlates positively with hepato-renal damage. The gene discussed is SPN; the disease is obesity due to melanocortin 4 receptor deficiency.