TNF and Hypertension: At the same time, the pathogenic role of CRP and proinflammatory cytokines (TNF-α, IL-1β, IL-6) overexpression is well known in the maintenance of arterial hypertension, as well as in the development of cardiac and vessel remodeling, renal dysfunction, impairment of the contractile and relaxing myocardial ability, tolerance to exercise, and progression of heart failure [9,32,33,34].