In the elderly group, the multivariate/adjusted analysis (Table 2) showed that older age (OR = 1.075, P < 0.001) and malnutrition (OR = 2.611, P = 0.001) were risk factors for cognitive frailty, while higher educational level (OR = 0.616, P = 0.010), higher social support level (OR = 0.473, P < 0.001), higher albumin level (OR = 0.904, P = 0.010), and larger calf circumference (OR = 0.904, P = 0.024) were protective factors against cognitive frailty. The gene discussed is ALB; the disease is nutritional deficiency disease.