ALB and major depressive disorder: The univariate/unadjusted analysis (Table 1) showed that in the elderly group, those with cognitive frailty were older (P < 0.001) and had a higher proportion of women (P = 0.037), lower educational level (P = 0.002), higher comorbidity status (P < 0.001), lower calf circumference (P < 0.001), lower hemoglobin level (P = 0.049), lower albumin level (P = 0.033), lower phosphorus level (P = 0.040), higher incidence of malnutrition (P < 0.001) and depression (P = 0.027), and lower social support level (P < 0.001) than those without cognitive frailty.