CD274 and neoplasm: Despite the established tumor-promoting role of EV within the tumor microenvironment, it has not been clarified at all, whether EVs derived from liquid biopsies of the blood and/or their subpopulations of PD-L1 and PD-L2 are meaningful surrogate marker(s) for disease progression or potential meaningful selection element(s) for PD-1 ICI therapy approaches in TNBC.