TARDBP and amyotrophic lateral sclerosis: TDP-43 pathology is one of the most common age-related pathologies [6, 23, 24, 27], initially described in patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) [12, 34, 44], and thereafter recognized in other diseases [3, 5, 6, 11, 29, 51].