found that calpain activity was up‐regulated under hypoxia, resulting in cleavage of filamin A (FLNA), generating a fragment that promoted nuclear localization of HIF‐1α, which was corecruited to HIF‐1α target gene promoters, ultimately leading to HIF‐1α target gene expression increased in hypoxia‐dependent manner in tumour. This evidence concerns the gene FLNA and neoplasm.