Accumulated evidence indicates that pathological cardiac hypertrophy invariably induces cardiomyocyte death, interstitial fibrosis, myocardial inflammation, diastolic and systolic dysfunction, accompanied by an increased size and mass of myocardial cells and up‐regulation of foetal gene (atrial natriuretic peptide [ANP], collagen I, β‐myosin heavy chain [β‐MHC]) expressions.4, 5, 6, 7. The gene discussed is NPPA; the disease is cardiac hypertrophy.