In the present study, AngII obviously up‐regulated the protein expressions of p‐STAT3 and p‐JAK2 and increased the level of p‐STAT3 nuclear translocation, while PM down‐regulated all these changes, suggesting that PM afforded protection against AngII‐induced myocardial hypertrophy by regulating the JAK2/STAT3 signalling pathway. Here, STAT3 is linked to cardiac hypertrophy.