PSEN1 and Alzheimer disease: In support of this conclusion, data released by the UK Biobank while this manuscript was in revision (https://genebass.org/gene/ENSG00000080815/phenotype/icd_first_occurrence-131036-both_sexes--?resultIndex=gene-manhattan&resultLayout=small) demonstrate that the PSEN1 S132A mutation is not associated with AD (P = 0.8).