RUNX1 and acute myeloid leukemia: Based on whole genome sequencing (WGS) of pediatric acute myeloid leukemia (AML), we recently reported that SBS18 – a signature characterized by frequent C > A transversions – is enriched in t(8;21)(q22;q22)/RUNX1::RUNX1T1-positive cases [3] (gene fusion designation according to recent guidelines [4]).