In fact, our knowledge of SBSsigns is rudimentary—and non-existing as regards IDsigns—in adult core binding factor (CBF) AML, which consists of cases positive for either RUNX1::RUNX1T1 or CBFB::MYH11 [inv(16)(p13q22)/t(16;16)(p13;q22)] [7]. Here, RUNX1 is linked to acute myeloid leukemia.