Moreover, we evaluated the survival of patients with advanced PCa with regard to OPRK1 amplification status using c-BioPortal and found that patients with OPRK1 amplification had significantly shorter survival compared with those without OPRK1 amplification (P = 5.823 × 10−4, log-rank test, Supplementary Fig. S5d, e). Here, OPRK1 is linked to posterior cortical atrophy.