Two studies in CAD patients have revealed that increased levels of Cer(d18:1/16:0), Cer(d18:1/18:0) and Cer(d18:1/24:1) were associated with higher coronary plaque vulnerability, characterized with a higher lipid volume, necrotic core and a thinner fibrous cap using intravascular ultrasound and optical coherence tomography17,41. This evidence concerns the gene CBLN1 and coronary artery disorder.