For example, the most impactful feature from the transcriptomics data, the expression of gene HS3ST3A1, has been implicated in α-Synuclein aggregation in PD cellular models, as well as having been recently part of a novel GWAS finding associated with white matter hyperintensity burden in elderly populations (along with some aspects of cognitive decline)28,29. This evidence concerns the gene HS3ST3A1 and Mental deterioration.