LCK and melanoma: In addition to binding of Lck, AMG-47a was also found to bind kinases involved in cell death pathways, including MAPKs, such as p38α, at low nanomolar concentrations and JNK1-3 at mid nanomolar concentrations, with AMG-47a shown to reduce ERK1/2 phosphorylation in A375 human melanoma cells [71].