We also observed shared dysregulated L/R pairs in the cohort analysis in comparison to the twins dataset not only in the B-cell compartment (eg. CD72:SEMA4D, CD74:APP, CCL22:CCR4, LGALS9:HAVCR2, and CD40:CD40LG among others) but also in compartments beyond B cells such as activated CD4+ T cells (Fig. 6i, left panel, Supplementary Figs. 7e and  8a, b) As previously observed for DEGs, we detected additional dysregulated L/R pairs when focusing in CVID Ib subtype patients (eg. CCR6:CCL20, CXCL9:CXCR3, CXCL10:DPP4, and CD86:CTL4 among others) (Fig. 6i, right panel and Supplementary Data 15). The gene discussed is SEMA4D; the disease is common variable immunodeficiency.