Then, we assessed the protein expression levels by the H-score system in tissue microarray (TMA) of 78 CRC patients to identify FAP and SPP1 both specifically increased in tumor tissue compared with adjacent normal tissue (Fig. 5d, e) and found patients with high protein levels of FAP or SPP1 enrolled in this TMA cohort exhibited shorter OS (Fig. 5f, g). Here, SPP1 is linked to neoplasm.