The immune-related pathways, including inflammatory response, IL2/STAT5 signaling, and IL6/JAK/STAT3 signaling, were enriched not only in immune cell populations, such as myeloid cells and T/ILC cells, but also in MSCs and ECs in tumor compared to normal tissues (Fig. 2a), suggesting the involvement of MSCs and ECs in the immune response against colorectal cancer. This evidence concerns the gene IL2 and neoplasm.