FAP and neoplasm: The FAP+ fibroblasts (Diff = 42.4%, p = 0.0052), proliferating fibroblasts (Diff = 2.29%, p = 0.0099), and pericytes (Diff = 10.4%, p = 0.031) were markedly enriched in tumor tissue as compared to that from adjacent normal tissue, while NT5E+ fibroblasts (Diff = 14.7%, p = 0.0053), FGFR2+ fibroblasts (Diff = 19.3%, p = 0.015), ICAM1− telocytes (Diff = −6.53%, p = 0.0071), and MFAP5+ myofibroblasts (Diff = 9.84%, p = 0.0066) were enriched in tumor-adjacent normal tissue (Fig. 3b, c, Supplementary Figs. 2d and 4b).