In addition to the above-mentioned TWIST1, when compared to FGFR2+ fibroblasts and ICAM1+ telocytes, respectively, FAP+ fibroblasts showed higher expression of PRRX1 (Supplementary Fig. 4g, h), which is critical for tuning cancer-associated fibroblast activation and plasticity in cancer54. Here, FGFR2 is linked to cancer.