STAT3 and colorectal cancer: The immune-related pathways, including inflammatory response, IL2/STAT5 signaling, and IL6/JAK/STAT3 signaling, were enriched not only in immune cell populations, such as myeloid cells and T/ILC cells, but also in MSCs and ECs in tumor compared to normal tissues (Fig. 2a), suggesting the involvement of MSCs and ECs in the immune response against colorectal cancer.