To validate whether our cellular experimental system genocopies elevated HDAC expression, the protein expression of HDAC1/2/3 were analyzed in the glioma cells LN229, A172, U87MG, LN308, #1095 and #1095_IR and compared to the expression in untransformed, primary astrocytes and HUVECs (Fig. 1B). Here, HDAC9 is linked to central nervous system cancer.