CDC42EP3 and central nervous system cancer: These findings were also verified by the following Spearman correlation test that the pathological grade of glioma was significantly correlated with the CDC42EP3 expression pattern (rs = 0.631, p < 0.001, n = 165) and patients with high expression pattern of CDC42EP3 were more likely to recur (rs = 0.513, p < 0.001, n = 165).