On the other hand, considering the significant regulation of cell phenotypes by CDC42EP3 knockdown, it was demonstrated that the regulatory effects of CDC42EP3 knockdown on glioma failed on condition of CCND1 overexpression, indicative of the key role played by CCND1 in downstream of CDC42EP3 (Fig. S8–S10). This evidence concerns the gene CCND1 and glioma.