RIPK1 and myeloid sarcoma: Importantly, inhibiting necroptosis by Nec-1s, so far the most potent inhibitor of RIPK1 activity [10–12], protects mature oligodendrocytes from death [8, 13] and attenuates symptoms in a MS mouse model [14], indicating that inhibiting RIPK1 activity both protects myelin from demyelination and reduces neuroinflammation [8, 9, 14].