Moreover, an elevated TMAVA level (Q4) is also an independent predictor of 7-year cardiac death and transplantation risk even after adjustments for traditional cardiac risk factors (age, sex, smoking, SBP, diabetes, HDL, and LDL) (adjusted model 1) (hazards ratio [HR], 1.91; 95% CI: 1.39–2.62; P < 0.001) and eGFR with NTproBNP levels (adjusted model 2) (HR, 1.75; 95% CI: 1.06–2.86; P = 0.027) (Fig. 1b). This evidence concerns the gene NPPB and diabetes mellitus.