The effectiveness of vitamin K supplements for reducing oxidative stress and inflammation are likely due to the fact that vitamin K: (a) suppresses hyperglycemia [49, 50, 52, 58, 59]; (b) increases SOD (superoxide dismutase) and GSH (reduced glutathione), but reduces ROS (reactive oxygen species) via its antioxidant potential [49, 50]; (c) suppresses NF-Kß (nuclear factor kappa ß) production [49, 52]; and (d) reduces AGE (advanced glycation end products) formation [49, 50]. This evidence concerns the gene SOD1 and Hyperglycemia.