CCR4 and Hodgkins lymphoma: Moreover, evaluation of chemokines levels in patients with Hodgkin lymphoma (HL) revealed the overproduction of CCL17 and CCL22 chemokines by Hodgkin–Reed–Sternberg (HRS) cells that attracted the T helper 2 (Th2) and regulatory T cells (Tregs) through CCR4 interaction, so participated in the formation of immunosuppressive milieu [43].