MSLN and neoplasm: On the other hand, overexpression of CD33 surface marker on MDSCs with an immunosuppressive feature in whole blood and tumor stroma has been proposed for MDSCs depletion by Gemtuzumab ozogamicin immunotoxin that subsequently reestablished T cell proliferation and also reactivated anti-GD2 CAR T cells, anti-mesothelin CAR T cells, and anti-EGFRvIII CAR T cells [113].