In a study of FAP-specific CAR T cells in malignant pleural mesothelioma (MPM) as FAP expressing model, Schuberth and colleagues reported that FAP recognizing CAR T cells substantially destroyed FAP-positive targets in vitro (including mesothelioma cells and fibroblasts) and delayed the tumor growth in vivo evaluation [78]. This evidence concerns the gene FAP and malignant pleural mesothelioma.