For instance, liver toxicity observed following anti-CIAX-redirected T cells infusion in patients with metastatic renal cell carcinoma (RCC) as well as inflammatory autoimmune colitis revealed after treatment with carcinoembryonic antigen (CEA)-specific TCR-engineered T cells in patients with metastatic colorectal cancer [153, 154]. The gene discussed is CEACAM5; the disease is metastatic colorectal cancer.