In addition, in NSCLC cells we confirmed that SF3A3 could directly bind to PRMT5 (Fig. 8E and Figure S9E) and circSCAP weakened the SF3A3/PRMT5 complex formation by decreasing the protein level of SF3A3 but not PRMT5 (Fig. 8F), which was further validated when SF3A3 was downregulated by circSCAP overexpression and siRNAs treatment (Figure S9F and G). Here, SF3A3 is linked to non-small cell lung carcinoma.