As expected, circSCAP overexpression inhibited the malignance of NSCLC cells including the proliferation (Fig. 7A) and colony formation ability (Fig. 7B and Figure S7), but these phenotypes could be rescued by subsequent SF3A3 supplementation in vitro (Fig. 7A-B and Figure S7). The gene discussed is SF3A3; the disease is non-small cell lung carcinoma.