To this purpose, we performed immunoblotting and RT-PCR analysis for the NSCLC cells with circSCAP overexpression or knock-down and found that circSCAP could reduce SF3A3 protein level (Fig. 5G) but not mRNA level (Fig. 5H), indicating circSCAP might regulate SF3A3 expression in a posttranscriptional manner. The gene discussed is SF3A3; the disease is non-small cell lung carcinoma.