TP53 and neoplasm: Next, we performed CCK8 and transwell assay to explore the role of circSCAP in NSCLC cell lines with p53 mutation, and the results showed that in the mutant cell lines with partial activated p53 signaling circSCAP exerted a less tumor-suppressing function (Figure S10B,C,F-I) when compared to cell lines with wild-type p53 (Figs. 2 and 3), but no function in cell line with p53 null mutation (Figure S10D-I).