For example, rs1887428-JAK2 in inflammatory bowel disease [256], rs11789015-BARX1 in esophageal adenocarcinoma [88], rs4065275-ORMDL3 and rs8076131-ORMDL3 in asthma, [248] and rs11603334-ARAP1 in type 2 diabetes mellitus [34]. The gene discussed is ORMDL3; the disease is esophageal adenocarcinoma.