HIF1A and lung cancer: Figure 6a shows that the protein and mRNA levels of STIL were up-regulated in CL1-0, CL1-5, and NCI-H1229 cells under hypoxia, but that HIF1α depletion dramatically diminished the ability of hypoxia to induce STIL at the protein (Fig. 6a, upper panel) and mRNA (Fig. 6a, lower panel) levels in all three lung cancer lines.