The results showed that GINS4 had prognostic value in adrenocortical carcinoma (ACC, p = 0.0022), KIRC (p = 0.026), acute myeloid leukemia (LAML, p = 0.032), brain lower grade glioma (LGG, p = 2.5e−06), LIHC (p = 0.045), LUAD (p = 0.04), mesothelioma (MESO, p = 0.00024), pancreatic adenocarcinoma (PAAD, p = 0.019), pheochromocytoma and paraganglioma (PCPG, p = 0.023), READ (p = 0.0019) and thymoma (THYM, p = 0.039) (Fig. 11). Here, GINS4 is linked to hereditary pheochromocytoma-paraganglioma.