Our study aimed to investigate the associations between Sirt1 rs7895833 A > G in the promoter region, Sirt1 rs2273773 C > T in the exon 5 silent mutation and Nrf2 rs6721961 C > A in the promoter region and metabolic syndrome risk in a Chinese Han population using polymerase chain reactions with two-pair primers (PCR-CTPP). This evidence concerns the gene SIRT1 and metabolic syndrome.