AFP and hepatocellular carcinoma: Recent evidence indicated miRNAs had a better performance compared with AFP in detection of early-stage HCV-HCC from CHC and LC, such as miR-331-3p, miR-23b-3p, miR-19a, miR-223, miR-122, miR-199a, miR-16, miR-101–1 and miR-221 [10, 14, 21, 24].