First, univariate logistic regression was used to screen CAD-related DEARGs, Fig. 5A showed there were 23 genes (ABHD5, ACSL1, ALPL, AMBRA1, ARHGAP26, CASP4, CEBPB, CFLAR, DDIT4, DENND3, FADD, FOS, GABARAPL1, GLIPR2, GPR18, LAMP2, LRRK2, MAPK14, MTMR3, NAMPT, NLRX1, NOD2, NRBF2, RALB, S100A8, TBC1D14, WDFY3) selected from 27 DEARGs. This evidence concerns the gene ACSL1 and coronary artery disorder.