In all, this study comprehensively evaluated the functions of autophagy in the diagnosis of CAD, we identified a 9-genes (TBC1D14, S100A8, NOD2, MTMR3, LAMP2, GABARAPL1, FADD, AMBRA1, ALPL) classifier for the first time that may represent diagnostic biomarker for CAD. This evidence concerns the gene MTMR3 and coronary artery disorder.