First, univariate logistic regression was used to screen CAD-related DEARGs, Fig. 5A showed there were 23 genes (ABHD5, ACSL1, ALPL, AMBRA1, ARHGAP26, CASP4, CEBPB, CFLAR, DDIT4, DENND3, FADD, FOS, GABARAPL1, GLIPR2, GPR18, LAMP2, LRRK2, MAPK14, MTMR3, NAMPT, NLRX1, NOD2, NRBF2, RALB, S100A8, TBC1D14, WDFY3) selected from 27 DEARGs. The gene discussed is NRBF2; the disease is coronary artery disorder.