In this case, it is likely that the severe genetically determined testicular impairment outweighed a possible trophic effect of GH, although this remains only speculative.In this context, a very peculiar pathological situation is represented by McCune-Albright syndrome, a genetically determined condition characterized by fibrous mono/poliostotic dysplasia, café-au-lait spots and endocrinopathies due to hyperfunction. This evidence concerns the gene GH1 and McCune-Albright syndrome.